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Skepticism refers to a questioning or doubting attitude towards knowledge, facts, or beliefs, often implying a reluctance to accept assertions without sufficient evidence. This concept is closely aligned with cynicism, which typically embodies a distrust of people's motives and a belief that individuals are primarily driven by self-interest.

Cynicism captures the essence of skepticism in that both involve a critical outlook and a tendency to question accepted truths or the intentions behind them. While trust, faith, and confidence suggest a more positive acceptance of information or beliefs, skepticism specifically entails a more analytical and critical perspective, making cynicism the most appropriate alternative among the provided choices.

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